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DD205-291
- Development stage
- Unknown
- Lead developer
- Huadong Medicine
- Modality
- PROTACs (E3 ligase recruitment) → Targeted Protein Degraders (TPDs) → Small Molecules, Bivalent/Multivalent Binders → Multivalent & Scaffold-Based Small Molecules → Small Molecules
01
Overview
DD205-291: sourced facts only. name: "Herein, we present a novel PROTAC-based HPK1 degrader compound DD205-291 with high selectivity and potency." [PMID:39446986]; target: "Herein, we present a novel PROTAC-based HPK1 degrader compound DD205-291 with high selectivity and potency." [PMID:39446986]; developer: "Global Drug R&D Center, Huadong Medicine, Hangzhou 310011, P. R. China." [PMID:39446986]; modality: "Herein, we present a novel PROTAC-based HPK1 degrader compound DD205-291 with high selectivity and potency." [PMID:39446986]; stage: "Specifically, oral administration of DD205-291 at 0.5 mg/kg in combination with anti-PD1 resulted in significant suppression with a TGI value of 91.0%." [PMID:39446986]
02
Targets
MAP4K1 (Hematopoietic progenitor kinase 1)
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