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deacetoxyvinzolidine
- Development stage
- Unknown
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules
01
Overview
Deacetoxyvinzolidine is a synthetic or semi-synthetic vinca alkaloid belonging to the class of indole alkaloids. It is structurally related to other vinca alkaloids such as vinblastine and vincristine, which are well-known for their antineoplastic (anticancer) properties. Vinca alkaloids act primarily by inhibiting tubulin polymerization into microtubules, thereby blocking spindle formation during mitosis and arresting cells in metaphase. This mechanism disrupts cell division and leads to apoptosis in rapidly dividing cancer cells. Deacetoxyvinzolidine has been studied as an experimental anticancer agent but has not been approved for clinical use[1][2][5][9]. Its development status remains experimental with no reported clinical trials beyond preclinical investigation.
- Other names
- deacetoxyvinzolidine3''-(beta-Chloroethyl)-2'',4''-dioxo-3,5''-spirooxazolidino-4-deacetoxyvinblastine
02
Targets
TUBB (Tubulin (alpha and beta subunits))
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