deacetylasperulosidic acid

Deacetylasperulosidic acid is a **naturally occurring iridoid glycoside** found in plants such as *Morinda citrifolia* (noni), *Gardenia jasminoides*, and *Galium rivale*[5][6]. It exhibits **antioxidant** activity by upregulating superoxide dismutase (SOD)[5][1][7][8], with evidence of dose-dependent reduction of oxidative markers in animal studies[5]. Deacetylasperulosidic acid also demonstrates **anti-inflammatory** properties by suppressing multiple cytokines and chemokines linked to inflammatory and allergic responses (e.g., TNF-α, IL-4, IL-6, IL-8, IL-1, IL-25, IL-33), reduces histamine secretion, and modulates MAPK/NF-kB signaling[1]. Additionally, it can restore immune balance, activate natural killer cells, and enhance IL-2 production[1][7]. In obesity models, deacetylasperulosidic acid binds peroxisome proliferator-activated receptor alpha (PPARα), decreases mature adipocyte proliferation, and significantly reduces triglyceride and cholesterol levels in animal models[1]. It also shows moderate activity in preventing SARS-CoV-2 spike protein binding to ACE2[1]. Its anticlastogenic effects are demonstrated by suppressing induction of chromosomal aberrations in cell and animal models[8]. The compound is primarily developed and studied as a **bioactive phytochemical** ingredient for research and nutraceutical purposes, especially in antioxidant and immune balance applications.

Other names

desacetylasperulosidic acid10-deacetylasperulosidic acidDEACETYLASPELUROSIDIC ACIDcyclopenta(c)pyran-4-carboxylic acid, 1alpha-(beta-D-glucopyranosyloxy)-1,4aalpha,5,7aalpha-tetrahydro-5beta-hydroxy-7-(hydroxymethyl)(1S,4aS,5S,7aS)-5-hydroxy-7-(hydroxymethyl)-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylic acid