Deceased Donor Kidney and Hematopoietic Cell Transplant

This experimental transplantation protocol, developed by Stanford University, is designed for patients with end-stage renal disease. The procedure involves a kidney transplant from a deceased donor followed by an infusion of hematopoietic stem cells (HSCs) harvested from the same donor's vertebral body. To facilitate the engraftment of these donor cells, patients undergo a conditioning regimen that includes lymphoid irradiation and anti-thymocyte globulin (ATG). The primary goal of this combined approach is to induce immune chimerism, a state where the recipient's immune system recognizes the donor organ as self. If successful, this allows for the significant reduction or complete elimination of long-term immunosuppressive medications, which are typically required to prevent organ rejection but carry substantial side effects.

Other names

Combined Deceased Donor Kidney and Hematopoietic Cell TransplantsDonor vertebral body marrow cell infusionDeceased Donor Kidney + Hematopoietic Cell Transplants-Stanford University-end-stage renal disease