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Decidua stromal cells (Akademiska sjukhuset)
- Development stage
- Unknown
- Lead developer
- Mats Remberger
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intravenous
01
Overview
Decidua stromal cells (DSCs) are allogeneic, placenta-derived mesenchymal-like cells isolated from the fetal membrane of term placentas. Developed by Mats Remberger and colleagues at Uppsala University Hospital, these cells are being investigated as a cell-based therapy for steroid-refractory acute graft-versus-host disease (aGVHD) following allogeneic hematopoietic stem cell transplantation. DSCs are characterized by potent immunosuppressive and immunomodulatory properties, which are reported to be more robust than those of bone marrow-derived mesenchymal stromal cells. The therapy works by modulating the immune response, specifically by suppressing donor T-cell activation and reducing the life-threatening inflammatory response associated with severe aGVHD.
- Other names
- Placenta-derived decidua stromal cellsMaternal stromal cellsDecidua stroma cells
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