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decitabine + nivolumab + tetrahydrouridine
- Development stage
- Unknown
- Lead developer
- Case Comprehensive Cancer Center
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Oral, Intravenous
01
Overview
A combination therapy consisting of decitabine, nivolumab, and tetrahydrouridine. Decitabine depletes DNA methyltransferase 1 (DNMT1), an enzyme often increased in cancer that suppresses neo-antigen expression. Tetrahydrouridine (THU) blocks cytidine deaminase, an enzyme that rapidly breaks down decitabine, thereby increasing the time cancer cells are exposed to decitabine. Nivolumab is an immune checkpoint inhibitor that blocks PD-1, enhancing T-cell immune response against cancer cells. This combination aims to overcome the limitations of using these drugs individually, particularly for solid tumors like non-small cell lung cancer (NSCLC).
- Other names
- THU-Dec/anti-PD1
02
Targets
DNMT1 (DNA (cytosine-5)-methyltransferase 1)PDCD1 (Programmed cell death protein 1 receptor)CDA (Cytidine deaminase)
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