declinol

Declinol is an **over-the-counter dietary supplement** formulated to support the reduction of alcohol cravings and consumption. Its composition is based on traditional herbal and botanical compounds, including **kudzu root extract (containing daidzin)**, **gentian (bitter herb)**, **tangerine peel**, **radix bupleuri**, **rehmannia**, **licorice root**, and a **blend of B vitamins and other micronutrients**. The supplement leverages the mechanism of **daidzin from kudzu**, a **selective inhibitor of aldehyde dehydrogenase 2 (ALDH-2)**, which leads to the accumulation of acetaldehyde during alcohol metabolism, producing aversive effects that can reduce alcohol intake. Declinol also incorporates bitters that stimulate gut TAS2R receptors, thought to synergistically reduce alcohol cravings, while additional ingredients such as radix bupleuri may have neuroprotective effects, modulating neurotransmitters (endorphins, dopamine, epinephrine). The formulation uses **encapsulation technology** for enhanced bioavailability of active phytonutrients.

Brand names

Declinol

Other names

declinol