Drug intelligence / Profile preview

DECOY20 + tislelizumab

Development stage
Unknown
Lead developer
Indaptus Therapeutics
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration
Intravenous
01

Overview

**DECOY20 + tislelizumab** is a combination investigational cancer immunotherapy comprising DECOY20, a novel, intravenously administered, multiple Toll-like receptor (TLR) agonist, and tislelizumab, a monoclonal antibody PD-1 checkpoint inhibitor. DECOY20 is engineered to activate both the innate and adaptive immune system, aiming to enhance and broaden the anti-tumor effect of checkpoint inhibitors. Tislelizumab blocks programmed death-1 (PD-1) receptor on T cells, preventing tumor cells from evading immune detection and restoring anti-cancer immune response. The combination is under clinical evaluation to improve response rates in patients with advanced solid tumors, who may not respond adequately to checkpoint inhibition alone[1][3][7].

Other names
DECOY20DECOY-20DECOY 20tislelizumabTevimbra
02

Targets

PDCD1 (Programmed cell death protein 1 receptor)TLR (Toll-like receptors)NLRP6 inflammasomeSTING (Stimulator of interferon genes protein)

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