deep neuromuscular blockade-Seoul National University Hospital

Deep neuromuscular blockade-Seoul National University Hospital refers to a specific pharmacological intervention protocol evaluated in clinical trials conducted by Seoul National University Hospital. This technique involves the administration of the non-depolarizing neuromuscular blocking agent rocuronium at high doses (typically an induction dose of 0.8 mg/kg followed by maintenance doses of 0.3 mg/kg) to achieve a profound state of muscle relaxation, defined by a post-tetanic count (PTC) of 1-2 twitches. The protocol is primarily investigated for its utility in laparoscopic colorectal surgery, where it is used in conjunction with low-pressure pneumoperitoneum to improve surgical field conditions and minimize the adverse cardiopulmonary effects associated with the Trendelenburg position and standard intra-abdominal pressures. The blockade is typically reversed using sugammadex.

Other names

deep neuromuscular blockadedeep NMB