DEEs suppressor tRNA program

Tevard Biosciences is developing a suppressor tRNA-based gene therapy for developmental and epileptic encephalopathies (DEEs) caused by nonsense mutations. The therapy utilizes engineered suppressor tRNAs delivered via adeno-associated virus (AAV) vectors to target and suppress premature stop codons across various genes implicated in DEEs, such as those involved in Dravet syndrome. By inserting a normal amino acid at the site of a premature stop codon, the therapy restores the production of full-length, functional proteins. This "basket" approach allows for the treatment of multiple genetic causes of DEEs with a single therapeutic modality by targeting the mutation type (nonsense) rather than a specific gene sequence.

Other names

Developmental and epileptic encephalopathies suppressor tRNA programDEEs Program