Drug intelligence / Profile preview

DehydraTECH-remdesivir

Development stage
Preclinical
Lead developer
Lexaria Bioscience
Modality
Small Molecules
Administration
Oral
01

Overview

DehydraTECH-remdesivir is an investigational oral formulation of the antiviral drug remdesivir, developed by Lexaria Bioscience (through its subsidiary Cannabis Delivery Sciences). The formulation utilizes Lexaria's proprietary DehydraTECH drug delivery platform, which is designed to enhance the oral bioavailability and performance of lipophilic active pharmaceutical ingredients. Remdesivir is a small molecule nucleotide analog that acts as an inhibitor of the viral RNA-dependent RNA polymerase (RdRp). While remdesivir is traditionally administered intravenously for the treatment of COVID-19 (SARS-CoV-2), the DehydraTECH formulation aims to enable effective oral delivery by improving absorption through the gastrointestinal tract and potentially bypassing first-pass liver metabolism via the lymphatic system. This candidate is being explored for antiviral applications, including COVID-19 and hepatitis.

Other names
remdesivir (DehydraTECH formulation)
02

Targets

RdRp (Coronavirus RNA-dependent RNA polymerase)

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