delapril

Delapril is an oral, lipophilic, nonsulfhydryl angiotensin-converting enzyme (ACE) inhibitor used primarily for the treatment of essential hypertension. It acts as a prodrug and is converted in the body to two active metabolites, 5-hydroxy delapril diacid and delapril diacid. These metabolites bind to and inhibit ACE, blocking the conversion of angiotensin I to angiotensin II. This inhibition leads to vasodilation by preventing the vasoconstrictive effects of angiotensin II and reduces aldosterone secretion from the adrenal cortex, resulting in increased sodium excretion and water outflow. Delapril is marketed in some European and Asian countries but not in America[1][2][5][6].

Brand names

Delapril

Other names

Delapril hydrochloridealindapril