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Drug intelligence / Profile preview
delayed-release ox bile extract
- Development stage
- Unknown
- Lead developer
- Mirum Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Delayed-release ox bile extract is an enteric-coated formulation of conjugated bile acids sodium developed by the Mayo Clinic in collaboration with Satiogen for the treatment of type 2 diabetes mellitus and obesity. Designed for ileocolonic delivery, the medication bypasses the upper gastrointestinal tract to stimulate enteroendocrine L cells in the distal gut. This stimulation triggers the secretion of fibroblast growth factor 19 (FGF-19) and various incretins, including glucagon-like peptide-1 (GLP-1), oxyntomodulin, and peptide YY (PYY3-36). These biological mediators work together to improve insulin sensitivity, regulate postprandial glycemia, and induce weight loss. The drug has been evaluated in Phase 2 clinical trials (notably NCT02871882) as an add-on therapy for patients already receiving dipeptidyl peptidase-4 (DPP4) inhibitors.
- Other names
- conjugated bile acids sodiumox bile extractileocolonic ox bile extractileocolonic formulation of ox bile extract
02
Targets
FXR (Farnesoid x-activated receptor)GPBAR1
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