Drug intelligence / Profile preview

delta-8-tetrahydrocannabinol

Development stage
Phase 1
Modality
Small Molecules
Administration
Inhalation, Oral, Sublingual, Topical
01

Overview

Delta-8-tetrahydrocannabinol (delta-8 THC) is a psychoactive cannabinoid found in the Cannabis sativa plant. It is an isomer of delta-9-tetrahydrocannabinol (delta-9 THC), the primary psychoactive component of cannabis. Delta-8 THC occurs naturally in very low concentrations and is typically produced by chemical conversion from hemp-derived cannabidiol (CBD). Its mechanism of action involves binding to cannabinoid receptor type 1 (CB1) and cannabinoid receptor type 2 (CB2) in the endocannabinoid system, resulting in psychoactive effects similar to but milder than those produced by delta-9 THC. Delta-8 THC has been used for effects such as pain reduction, sleep support, increased relaxation, and improved appetite[1][3][4][5][6]. The compound gained popularity after changes in U.S. law allowed for hemp-derived cannabinoids to be marketed more widely.

Other names
(−)-trans-Δ8-tetrahydrocannabinol
02

Targets

CNR1 (Cannabinoid receptor 1)

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