Drug intelligence / Profile preview

Deltamethrin

Development stage
Unknown
Modality
Small Molecules
Administration
Intranasal
01

Overview

Deltamethrin is a pyrethroid pesticide widely utilized for vector control across various sectors, including crops, farming, veterinary medicine, and domestic pest control. Research indicates that repeated exposure to Deltamethrin can lead to neurotoxic effects. Specifically, studies in rats have demonstrated that intranasal administration induces memory and emotional alterations, accompanied by a reduction in tyrosine hydroxylase immunoreactivity in the substantia nigra pars compacta and ventral tegmental area, and an increase in the dorsal striatum. These findings suggest that Deltamethrin can cause an early disruption of the dopaminergic pathway, similar to observations in the initial stages of Parkinson's disease.

Other names
DM
02

Targets

NaV (Voltage-gated sodium channels)NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)DRD2 (Dopamine D2 Receptor)DRD1 (Dopamine D1 Receptor)TH (Tyrosine hydroxylase)

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