demethoxy feruloyl acetone

Demethoxy feruloyl acetone is a natural degradant of curcumin formed during heating, structurally similar to feruloylacetone but lacking a methoxy group on the aromatic ring[1][3]. It has demonstrated **antiproliferative and proapoptotic effects in colon cancer cell models**, specifically inhibiting proliferation and inducing cell cycle arrest (G2/M phase) and apoptosis, with mechanisms involving suppression of the phosphorylated mTOR/STAT3 pathway and activation of p53/p21 and cyclin-B1[1][3][5]. DFER also induces ROS elevation and mitochondrial changes in cancer cells. It has shown antioxidant activity, though markedly less than feruloylacetone[3]. Recently, DFER has been studied for its **potential to mitigate obesity-related glucose intolerance and muscle atrophy**, indicating possible metabolic benefits[5].

Other names

demethoxy feruloylacetoneDFER