demineralized dentin allograft

Demineralized dentin allograft (DDA) is a regenerative biomaterial derived from processed human donor teeth, primarily utilized in dental and maxillofacial surgery for bone augmentation and alveolar ridge preservation. Biochemically similar to bone, dentin consists of an inorganic mineral phase and an organic matrix rich in Type I collagen and sequestered bioactive molecules, including bone morphogenetic proteins (BMPs) and transforming growth factor-beta (TGF-β). The demineralization process removes the hydroxyapatite component to expose these growth factors, making them bioavailable to the recipient site. DDA functions through both osteoconduction, providing a structural scaffold for host bone growth, and osteoinduction, where released proteins signal the differentiation of mesenchymal stem cells into osteoblasts. It offers a sustainable and scalable alternative to autogenous bone grafts, eliminating donor-site morbidity while maintaining high biocompatibility and effectiveness in maintaining ridge volume post-extraction.

Other names

DDAallogenic dentin graftdemineralized allogenic dentin matrixallogeneic demineralized dentin matrix