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dendritic cell loaded livin peptide
- Development stage
- Unknown
- Lead developer
- Third Military Medical University
- Modality
- Dendritic Cell Vaccines → Immune Effector Cells → Other Cell Types → Cell Therapies, Peptides, Vaccines & Immunotherapeutics
- Administration
- Intravenous
01
Overview
Dendritic cell loaded livin peptide is an autologous dendritic cell (DC) vaccine designed to treat non-small cell lung cancer (NSCLC). The therapy involves harvesting a patient's own dendritic cells and pulsing them with peptides derived from Livin (also known as BIRC7), a member of the Inhibitor of Apoptosis Protein (IAP) family that is frequently overexpressed in various malignancies and associated with resistance to therapy. These antigen-loaded DCs are then re-administered to the patient to prime and activate a specific cytotoxic T lymphocyte (CTL) response against tumor cells expressing the Livin protein. In clinical studies, this cell therapy has been investigated as a sensitization agent to enhance the efficacy of radiotherapy in patients with middle or terminal stage NSCLC, often in conjunction with cytokine-induced killer (CIK) cell therapy.
- Other names
- DC loaded Livin peptideLivin-peptide-pulsed dendritic cellsdendritic cells load the livin peptide
02
Targets
TCR (T-cell receptor recognizing livin-derived peptide–MHC class I complex)MHC I (MHC class I})BIRC7 (Baculoviral IAP repeat-containing protein 7 (Livin))
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