Drug intelligence / Profile preview

dendrobii caulis

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

Dendrobii caulis refers to the stem of plants from the genus Dendrobium, particularly Dendrobium officinale, widely used in traditional Chinese medicine and as a functional food in East Asia[2][3]. It is consumed for its purported health benefits including anti-inflammatory, antinociceptive (pain-relieving), and eye-protective effects[2][3][5]. Recent research has shown that extracts of dendrobii caulis can relieve neuropathic pain by modulating the transient receptor potential vanilloid 1 receptor (TRPV1) in the spinal cord[2]. The plant contains various bioactive compounds such as polysaccharides and picrotoxane-type sesquiterpenes; these are believed to contribute to its pharmacological activities including anti-inflammatory action via inhibition of proinflammatory cytokines like TNF-α and IL-1β[3], antioxidant effects, cytoprotection against oxidative stress in retinal cells[5], and possible anticancer properties. It is also marketed as a dietary supplement for general wellness or specific uses such as improving vision or nourishing yin energy according to traditional concepts[4].

Other names
D. caulisDendrobium officinale caulis石斛 (Shihu)Dendrobium stem
02

Targets

TNFA (Tumor necrosis factor alpha (soluble))TRPV1 (Transient receptor potential cation channel subfamily V member 1)IL1B (Interleukin-1 beta)

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