dendrobine

**Dendrobine** is a naturally occurring tetracyclic sesquiterpene alkaloid chiefly isolated from the medicinal orchid Dendrobium nobile Lindl. It displays a range of pharmacological activities including neuroprotective, antiviral (notably anti-influenza activity), anticancer (notably pro-apoptotic effects in cancer cell lines), anxiolytic, and anti-inflammatory effects. Mechanistically, dendrobine antagonizes β-alanine and taurine in the central nervous system and modulates presynaptic inhibition. It inhibits influenza A viral replication via binding the viral nucleoprotein (NP), restraining NP nuclear export, and impeding NP oligomerization. In oncology models, dendrobine promotes mitochondrial-dependent apoptosis through upregulating pro-apoptotic Bax and downregulating anti-apoptotic Bcl-2. Neuropharmacological studies indicate enhancement of neurotransmission, synaptic function, and serotonin levels, suggesting potential roles in neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease, and in mood regulation[1][2][4][6][7][13][15].

Other names

(-)-Dendrobine(1S,4S,7S,8S,11S,12R,13S)-2,12-Dimethyl-13-propan-2-yl-10-oxa-2-azatetracyclo[5.4.1.1^8,11^.0^4,12^]tridecan-9-one