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Dendrobium fimbriatum Hook plant-derived exosome-like nanovesicles
- Development stage
- Preclinical
- Lead developer
- China Medical University
- Modality
- Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Topical
01
Overview
Dendrobium fimbriatum Hook plant-derived exosome-like nanovesicles (DF-PDENs) are plant-derived exosome-like nanovesicles isolated from the stems of the traditional Chinese medicinal herb *Dendrobium fimbriatum* Hook. These biocompatible nanovesicles exhibit immunomodulatory and anti-inflammatory properties. In preclinical studies, DF-PDENs have demonstrated the ability to suppress inflammatory responses in human keratinocyte models stimulated with TNF-α and IL-17, as well as in murine T-cell models stimulated with IL-17 and IFN-γ, by reducing the production of proinflammatory cytokines such as IL-6 and IL-8. DF-PDENs are being investigated as a potential novel nanotherapeutic for the treatment of chronic immune-mediated skin disorders, such as psoriasis and atopic dermatitis.
- Other names
- Dendrobium fimbriatum Hook-derived exosome-like nanovesiclesDendrobium fimbriatum plant-derived exosome-like nanovesicles
02
Targets
AKT (RAC-alpha serine/threonine-protein kinase)ICAM1 (Intercellular Adhesion Molecule 1)IL1B (Interleukin-1 beta)IL-6 (Interleukin 6)VEGFR2 (Vascular endothelial growth factor receptor 2)NOS3 (eNOS)
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