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This preclinical vaccine candidate, developed by Asia Biotech Group, utilizes an adenoviral vector platform to prevent dengue fever. The vaccine is engineered to express the Dengue virus coat protein E (envelope protein), which is the primary antigenic component responsible for viral attachment and entry into host cells. By delivering the genetic code for this protein via a non-replicating adenoviral vector, the vaccine aims to stimulate a comprehensive immune response, including the production of neutralizing antibodies and the activation of cellular immunity. This approach is intended to provide protection against infection by the dengue virus and is currently undergoing preclinical evaluation.
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