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dengue virus serotype 2 expressing dengue virus serotype 3 surface proteins, live attenuated
- Development stage
- Unknown
- Lead developer
- Umeå University
- Modality
- Live Attenuated Vaccines → Live Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Subcutaneous
01
Overview
dengue virus serotype 2 expressing dengue virus serotype 3 surface proteins, live attenuated is a monovalent, live-attenuated chimeric vaccine candidate developed for the prevention of dengue fever caused by serotype 3. The vaccine utilizes a recombinant technology where the genetic backbone of an attenuated dengue virus serotype 2 (DENV-2) is modified to express the pre-membrane (prM) and envelope (E) structural proteins of dengue virus serotype 3 (DENV-3). This chimeric structure allows the virus to maintain the attenuation characteristics of the DENV-2 parent while presenting the critical neutralizing epitopes of DENV-3 to the host immune system. Developed in part through research at Umea University and sponsored by Region Vaesterbotten, this candidate has been evaluated in Phase 1 clinical trials to determine its safety and ability to induce serotype-specific neutralizing antibodies in flavivirus-naive populations.
- Other names
- chimeric DENV-2/3 vaccineDENV-2/3
02
Targets
Human B-cell receptor recognizing dengue virus serotype 3 envelope proteinDENV-3 E (Dengue virus serotype 3 envelope protein)prM (Zika virus precursor membrane protein)
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