Drug intelligence / Profile preview

Dengyin Naotong

Development stage
Unknown
Lead developer
Shandong Second Provincial General Hospital
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Dengyin Naotong is a Traditional Chinese Medicine (TCM) formulation, typically administered as a capsule, used for the treatment of cerebrovascular and cardiovascular conditions. It is a combination of extracts from *Erigeron breviscapus* (Dengzhanxihua) and *Ginkgo biloba* (Yinxingye). The drug is characterized by its ability to improve cerebral blood flow, inhibit platelet aggregation, and provide neuroprotective effects against ischemic damage. Its active constituents, including scutellarin and ginkgolides, contribute to its therapeutic profile by modulating microcirculation and reducing oxidative stress. Dengyin Naotong is approved in China and is currently being evaluated in clinical trials, such as the De-CSVD study (ChiCTR2100045831), for its efficacy in treating mild cognitive impairment (MCI) associated with cerebral small vessel disease (CSVD).

Brand names
Dengyin Naotong Capsule
Other names
Dengyin Naotong Jiaonang灯银脑通
02

Targets

PTAFR (Platelet-activating factor receptor)

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