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denikitug
- Development stage
- Phase 2
- Lead developer
- Gilead Sciences
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
Denikitug (GS-1811, JTX-1811) is an investigational monoclonal antibody that targets C-C chemokine receptor type 8 (CCR8). It is designed to selectively deplete CCR8-expressing regulatory T cells (Tregs) within the tumor microenvironment through mechanisms including direct inhibition of CCR8 and antibody-dependent cell-mediated cytotoxicity (ADCC). By reducing immunosuppressive Tregs in tumors, denikitug aims to enhance anti-tumor immune responses. The drug is being developed for the treatment of advanced solid tumors and is currently in Phase 1 clinical trials as both monotherapy and in combination with zimberelimab, an anti-PD-1 monoclonal antibody. Denikitug was originally developed by Jounce Therapeutics and further developed by Gilead Sciences[1][3][5].
- Other names
- afucosylated anti-CCR8 monoclonal antibody
02
Targets
CCR8
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