deoxycorticosterone acetate

**Deoxycorticosterone acetate** is a synthetic **mineralocorticoid** steroid hormone ester, chemically identified as the C21 acetate ester of 11-deoxycorticosterone. It acts as a prodrug, releasing active deoxycorticosterone after intramuscular injection. Deoxycorticosterone acetate functions as a potent mineralocorticoid, primarily *increasing renal tubular sodium reabsorption* and promoting potassium excretion, mimicking the biological effects of aldosterone. Its mechanism involves binding mineralocorticoid receptors in the cytoplasm of renal tubular cells, leading to gene transcription and upregulation of protein synthesis responsible for electrolyte homeostasis. It has historically been used in adrenal insufficiency (Addison’s disease), especially before the availability of fludrocortisone, but is primarily used now as an animal pharmaceutical for replacement therapy in veterinary medicine[1][2][3][5]. In research, it is widely used to induce hypertension in laboratory animal models[4][8].

Brand names

Percorten AcetateDecosteronePercotolCortacetCortenilSyncortylSincortex

Other names

desoxycorticosterone acetatedesoxycortone acetatedeoxycorticosterone-21-acetatedeoxycorticosterone21-acetatedeoxycorticosterone 21-acetatecortexone acetatedesoxycorticosterone 21-acetatedesoxycorticosterone21-acetatedesoxycorticosterone-21-acetatedoc 21 acetatedoc21 acetatedoc-21 acetatedoc-acetate