deoxypodophyllotoxin

Deoxypodophyllotoxin is a natural flavonolignan and a derivative of podophyllotoxin. It is classified as a small molecule tubulin inhibitor with potent antimitotic activity. Deoxypodophyllotoxin destabilizes microtubules by inhibiting tubulin polymerization and exhibits significant antitumor effects through cell cycle arrest and induction of apoptosis. It also inhibits angiogenesis and has demonstrated anti-inflammatory and antiviral properties. Mechanistically, it can inhibit the HIF-1α signaling pathway (reducing glycolysis in cancer cells), competitively bind to EGFR and MET kinases (suppressing their downstream signaling), induce reactive oxygen species (ROS) generation leading to endoplasmic reticulum stress and apoptosis via multi-caspase activation[3][4][6]. The compound is being developed primarily for oncology indications such as advanced malignant solid neoplasms[1]. Its originator organization is Shenyang Pharmaceutical University.

Other names

Anthricin(-)-Deoxypodophyllotoxin4-DeoxypodophyllotoxinIsoanthricinHernandionHernandin