Depigmented polymerized Dermatophagoides pteronyssinus + Lepidoglyphus destructor allergen extract

Depigoid DUO is a brand of depigmented, polymerized allergen extract used for subcutaneous immunotherapy (SCIT) in patients with IgE-mediated respiratory allergies, particularly allergic rhinitis and/or rhinoconjunctivitis due to sensitization to house dust mites (*Dermatophagoides pteronyssinus*) and storage mites (*Lepidoglyphus destructor*). The product contains a mixture of these two mite allergens that have been chemically modified (depigmented and polymerized) to reduce their allergenicity while maintaining immunogenicity. This modification allows for safer administration at higher doses, aiming to induce immune tolerance by shifting the immune response from an IgE-mediated allergic profile towards increased production of specific IgG antibodies and regulatory cytokines. Depigoid DUO is indicated primarily for patients who do not respond adequately to environmental avoidance or symptomatic treatments[1][4][7]. **Developers:** LETI Pharma SLU **Manufacturers:** LETI Pharma SLU Depigoid DUO is specifically formulated as a combination therapy for polyallergic patients sensitized to both grass pollens and olive pollen or multiple mite species. It is administered via subcutaneous injection using an ultra-rapid regimen followed by maintenance dosing every four weeks[1][4]. Clinical trials support its efficacy in reducing symptoms and medication use in allergic rhinitis/rhinoconjunctivitis[3][7].

Brand names

Depigoid DUO

Other names

Depigoid DUO