Drug intelligence / Profile preview

Depigoid Acarus siro

Development stage
Unknown
Lead developer
Leti Pharma
Modality
Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics
Administration
Subcutaneous
01

Overview

Depigoid Acarus siro is a depigmented, polymerized allergen extract used for subcutaneous immunotherapy (SCIT) targeting allergy to the storage mite *Acarus siro* (flour mite). The product is designed to desensitize individuals with IgE-mediated allergy to *Acarus siro*, which can cause symptoms such as asthma, rhinitis, skin reactions, and in rare cases anaphylaxis. The mechanism of action involves gradual exposure to increasing doses of the allergen extract, leading to immune tolerance and reduction in allergic symptoms. Depigoid extracts are specifically processed by depigmentation and polymerization to reduce allergenicity while maintaining immunogenicity. This therapy is primarily indicated for patients with confirmed sensitization and clinical symptoms due to *Acarus siro* exposure[1][7].

Brand names
Depigoid Acarus siro
02

Targets

A. annua-specific IgE (Artemisia annua-specific immunoglobulin E)T cell receptor recognizing Acarus siro allergen-derived peptides presented on MHC class II

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