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deproteinized asparagus polysaccharide
- Development stage
- Preclinical
- Administration
- Oral, Intraperitoneal, Intravenous
01
Overview
Deproteinized asparagus polysaccharide is a bioactive carbohydrate extracted from *Asparagus officinalis* that has undergone protein removal, typically via the Sevag method. It demonstrates significant anticancer activity, particularly against hepatocellular carcinoma (HCC), by inducing G2/M phase cell cycle arrest and promoting apoptosis. Mechanistically, it modulates the expression of apoptosis-related proteins, including the upregulation of Bax and caspase-3 and the downregulation of Bcl-2. Additionally, it has been shown to act as a chemosensitizer, enhancing the tumoricidal efficacy of chemotherapeutic agents like mitomycin in both in vitro and in vivo models.
- Other names
- deproteinized Asparagus officinalis polysaccharideDAP
02
Targets
BAX (Apoptosis regulator BAX)CASP3 (Caspase-3)
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