dequalinium chloride

Pregyn is an antiseptic vaginal tablet containing dequalinium chloride, developed and marketed by MacroPhar for the treatment of bacterial vaginosis (BV). Dequalinium chloride is a quaternary ammonium cation that functions as a broad-spectrum antimicrobial agent. It is effective against a wide range of Gram-positive and Gram-negative bacteria, as well as certain fungi and protozoa. The drug exerts its therapeutic effect by increasing the permeability of bacterial cell membranes and inhibiting vital enzymatic activities, which leads to the loss of cellular components and subsequent cell death. As a non-antibiotic treatment, it serves as an alternative to traditional therapies like metronidazole or clindamycin, particularly in regions where it is approved as an over-the-counter or prescription generic product.

Brand names

Pregyn

Other names

dequalinium