Drug intelligence / Profile preview

deracoxib

Development stage
Unknown
Lead developer
Novartis
Modality
Small Molecules
Administration
Oral
01

Overview

Deracoxib is a non-steroidal anti-inflammatory drug (NSAID) of the coxib class, used in veterinary medicine—primarily in dogs—to control pain and inflammation associated with osteoarthritis, orthopedic surgery, and dental surgery. It acts by selectively inhibiting cyclooxygenase-2 (COX-2), an enzyme responsible for the synthesis of inflammatory prostaglandins, while sparing cyclooxygenase-1 (COX-1) at recommended doses. This selectivity reduces pain and inflammation with fewer gastrointestinal side effects compared to non-selective NSAIDs. Deracoxib is administered orally as a chewable tablet and was first approved for use in dogs in 2002 under the trade name Deramaxx[1][2][3][5][6][7].

Brand names
Deramaxx
Other names
deracoxib
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)

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