Drug intelligence / Profile preview

Dermama Exosome-MSC

Development stage
Phase 3
Lead developer
Eli Lilly
Modality
Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
Administration
Intravenous
01

Overview

**Dermama Exosome-MSC** is a mesenchymal stem cell-derived exosome therapy developed by PT Dermama Bioteknologi Laboratorium for reducing hyper-inflammation. It contains bioactive cargo including anti-inflammatory cytokines, growth factors, mRNA, and miRNA, delivered via exosomes (30-100 nm vesicles) that communicate between cells. The mechanism involves immunomodulation on immune cells to relieve hyper-inflammation, miRNA-mediated inhibition of viral RNA (e.g., SARS-CoV-2) in infected cells to prevent replication, and growth factor stimulation of protein synthesis for organ regeneration in progenitor cells.[1][3][9]

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