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dermatophagoides allergen immunotherapy + lepidoglyphus allergen immunotherapy
- Development stage
- Unknown
- Lead developer
- Inmunotek
- Modality
- Subcutaneous Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Sublingual Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Subcutaneous
01
Overview
Dermatophagoides allergen immunotherapy + Lepidoglyphus allergen immunotherapy is a subcutaneous allergen immunotherapy (SCIT) product developed by Inmunotek S.L. It is composed of glutaraldehyde-modified (polymerized/allergoid) extracts from house dust mites (*Dermatophagoides pteronyssinus* and *Dermatophagoides farinae*) and the storage mite *Lepidoglyphus destructor*. The polymerization process reduces the IgE-binding capacity (allergenicity) while preserving the ability to induce a protective immune response (immunogenicity), thereby improving safety and allowing for faster up-dosing. The therapy is indicated for patients with moderate-to-severe allergic rhinitis or rhinoconjunctivitis, with or without mild-to-moderate controlled asthma, who are sensitized to these specific mite species. It is currently being evaluated in Phase III clinical trials to confirm its efficacy in inducing allergen-specific immune tolerance.
- Other names
- Dermatophagoides/Lepidoglyphus allergen immunotherapy
02
Targets
BCR (Immunoglobulin G B Cell Receptor)TCR (T cell antigen receptor complex)MHC II (Major histocompatibility complex class II receptor)TLR4 (Toll-like receptor 4)Lepidoglyphus destructor allergen
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