Drug intelligence / Profile preview

dermatophagoides farinae allergen

Development stage
Unknown
Lead developer
Wolwo Biotech
Modality
Sublingual Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Subcutaneous Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics
Administration
Sublingual
01

Overview

Dermatophagoides farinae allergen is a standardized allergen extract derived from the American house dust mite, Dermatophagoides farinae. It is primarily used in allergen-specific immunotherapy (AIT), specifically as sublingual immunotherapy (SLIT) drops, for the treatment of allergic rhinitis and allergic conjunctivitis in patients sensitized to house dust mites. The drug works by inducing peripheral immune tolerance, which involves the expansion of regulatory T cells (Tregs), the production of anti-inflammatory cytokines such as interleukin-10 (IL-10), and a shift from a Th2-mediated allergic response to a Th1-mediated response. This modulation leads to a decrease in allergen-specific IgE levels and a reduction in the activation of effector cells like mast cells and basophils. In China, this product is developed and manufactured by Zhejiang Wolwo Bio-Pharmaceutical under the brand name Chanllergen.

Brand names
Chanllergen
Other names
dermatophagoides farinae allergenAmerican house dust mite allergenDermatophagoides farinae extractDf allergen
02

Targets

Der f-specific IgE (Dermatophagoides farinae-specific IgE)Dermatophagoides farinae-specific T-cell receptors

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