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dermatophagoides farinae extract
- Development stage
- Phase 2
- Lead developer
- Jubilant HollisterStier
- Modality
- Sublingual Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Subcutaneous Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Sublingual, Subcutaneous, Intradermal, Intranasal, Inhalation
01
Overview
Dermatophagoides farinae extract is a standardized allergenic preparation derived from the American house dust mite. It is utilized for the diagnosis and treatment of Type I hypersensitivity reactions, including allergic rhinitis, allergic conjunctivitis, and allergic asthma. As a diagnostic agent, it is used in skin prick testing and provocation challenges to identify sensitization. As a therapeutic agent, it is the basis for allergen-specific immunotherapy (AIT), administered either subcutaneously (SCIT) or sublingually (SLIT). The extract contains a complex mixture of proteins, most notably the major allergens Der f 1 and Der f 2. The mechanism of action involves immune modulation, shifting the immune response from a Th2-dominated allergic profile to a Th1/Treg-mediated tolerant state, characterized by the induction of allergen-specific IgG4 antibodies and the suppression of IgE-mediated mast cell and basophil activation.
- Brand names
- ODACTRAAllermmune HDM
- Other names
- Dermatophagoides farinae allergen extractDer f extractDf extractAmerican house dust mite extract
02
Targets
IgE (Immunoglobulin E)
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