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Dermatophagoides pteronyssinus allergen extract + mixed respiratory bacterial extracts
- Development stage
- Unknown
- Lead developer
- Universidade Federal de Uberlândia
- Modality
- Sublingual Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Subcutaneous Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Sublingual
01
Overview
Dermatophagoides pteronyssinus allergen extract + mixed respiratory bacterial extracts (DPT+MRB) is a sublingual immunotherapy (SLIT) formulation investigated for the treatment of allergic rhinitis and asthma in children sensitized to house dust mites. Developed by the Federal University of Uberlandia in Brazil, the therapy combines mite allergen extracts (specifically from Dermatophagoides pteronyssinus) with a mixture of respiratory bacterial antigens. The mechanism of action involves allergen desensitization and immunomodulation, aiming to shift the immune response from a Th2-driven allergic profile toward tolerance. Clinical evaluation has focused on symptom reduction, medication score improvements, and changes in antibody profiles, including serum IgE, IgG4, and salivary IgA.
- Other names
- mite + bacterialDPT + MRBDermatophagoides pteronyssinus + mixed respiratory bacterial extracts
02
Targets
BL (Bacterial lysate (respiratory))
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