Drug intelligence / Profile preview

Dermatophagoides pteronyssinus allergoid

Development stage
Approved
Lead developer
ALK Abelló
Modality
Sublingual Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Subcutaneous Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics
Administration
Sublingual, Subcutaneous, Intradermal
01

Overview

Dermatophagoides pteronyssinus allergoid is an allergen extract derived from the house dust mite species Dermatophagoides pteronyssinus. It is used primarily in allergy testing and as immunotherapy for patients with house dust mite-induced allergic rhinitis (with or without conjunctivitis) and allergic asthma. The mechanism of action involves inducing immune tolerance by repeated exposure to the modified (allergoid) form of the allergen, thereby reducing hypersensitivity reactions upon natural exposure to dust mites. This therapy does not provide immediate symptom relief but aims to modify the underlying allergic response over time. It is administered either sublingually (as a tablet dissolved under the tongue) or via injection for diagnostic skin testing or subcutaneous immunotherapy[1][2][3][4][5]. The product is approved for use in patients aged 12 through 65 years[1].

Brand names
AcarizaxOdactraStandardized Mite Extract
Other names
Dermatophagoides pteronyssinus extracthouse dust mite allergen extractD. pteronyssinus extract
02

Targets

IgE antibodies specific to Dermatophagoides pteronyssinus allergens

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