Drug intelligence / Profile preview

Dermazulen

Development stage
Unknown
Lead developer
Institute of Organic Chemistry and Biochemistry of the CAS
Modality
Small Molecules
Administration
Topical
01

Overview

Dermazulen is a topical pharmaceutical ointment containing a combination of guaiazulene and chamomile oil. Developed by the Institute of Organic Chemistry and Biochemistry (IOCB) in Prague, it is widely used for its anti-inflammatory, anti-allergic, and antiseptic properties. The active ingredient, guaiazulene, is a dark blue sesquiterpene derivative obtained from chamomile (Matricaria chamomilla) that promotes skin healing and reduces irritation by inhibiting the release of inflammatory mediators. It is primarily indicated for the treatment of minor skin injuries, burns, eczema, and other inflammatory skin conditions.

Brand names
Dermazulen
Other names
guaiazulene + chamomile oil
02

Targets

Arachidonate 5-lipoxygenase pathwayPTGS2 (Prostaglandin-Endoperoxide Synthase 2)H (Histamine receptors)

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