Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
deserpidine
- Development stage
- Unknown
- Lead developer
- Abbott
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Deserpidine is an ester alkaloid drug isolated from the plant Rauwolfia canescens (family Apocynaceae). It has been used primarily as an antihypertensive agent for the treatment of high blood pressure and also possesses antipsychotic properties. Deserpidine acts by depleting noradrenaline stores in peripheral sympathetic nerve terminals and catecholamine and serotonin stores in the brain, heart, and other organs. This results in reduced blood pressure due to decreased cardiac output and peripheral resistance. Its mechanism of action involves inhibition of the ATP/Mg2+ pump responsible for sequestering neurotransmitters into storage vesicles within presynaptic neurons; neurotransmitters not stored are metabolized by monoamine oxidase (MAO), leading to a reduction in catecholamines[1][3][4][6]. Some sources also report that deserpidine competitively inhibits angiotensin converting enzyme (ACE), thereby reducing angiotensin II-induced aldosterone secretion[6][8].
- Brand names
- HarmonylEnduronylOreticyl Forte
- Other names
- deserpidine hydrochloride
02
Targets
VMAT2 (Vesicular monoamine transporter 2)ACE (Angiotensin Converting Enzyme)
Beyond the preview
Go deeper on deserpidine.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on deserpidine.