Deslanoside

Deslanoside is a cardiac glycoside derived from the leaves of *Digitalis lanata* (woolly foxglove). It is used for the treatment and management of congestive heart failure and various cardiac arrhythmias, including supraventricular arrhythmias due to reentry mechanisms and chronic atrial fibrillation. Deslanoside acts by inhibiting the sodium/potassium-transporting ATPase subunit alpha-1 (Na-K-ATPase) membrane pump in cardiac cells. This inhibition increases intracellular sodium and calcium concentrations, which enhances myocardial contractility (positive inotropic effect) and alters electrical activity in the heart by increasing phase 4 depolarization slope, shortening action potential duration, and decreasing maximal diastolic potential[1][2][3][4][5]. Deslanoside has also shown anticancer activity in preclinical studies involving prostate cancer cell lines[6].

Brand names

Cedilanide

Other names

desacetyldigilanide Cdeslanosidumdeslanosido