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desoximetasone
- Development stage
- Approved
- Lead developer
- Taro
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
- Administration
- Topical
01
Overview
Desoximetasone is a potent synthetic topical corticosteroid (glucocorticoid) used to treat inflammatory and pruritic corticosteroid-responsive dermatoses, including plaque psoriasis and eczema. It works by binding to the glucocorticoid receptor in skin cells, leading to changes in gene expression that suppress the production of pro-inflammatory mediators such as prostaglandins and leukotrienes. This results in reduced redness, swelling, itching, and discomfort associated with various skin conditions. Desoximetasone is available as a cream, ointment, gel, or spray for topical application[1][2][3][4][5][7][8].
- Brand names
- TopicortTopicort LPDesoxi
- Other names
- desoximetasoneDSXS
02
Targets
GR (Glucocorticoid receptor)ESRRA (Estrogen-related receptor alpha)ESRRB (Estrogen-related receptor beta)ESRRG (Estrogen-related receptor gamma)
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