Drug intelligence / Profile preview

Desoximetasone + salicylic acid

Development stage
Unknown
Lead developer
Taro
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Topical
01

Overview

Desoximetasone + salicylic acid is a topical combination therapy used for the treatment of inflammatory and hyperkeratotic skin conditions, such as psoriasis and corticosteroid-responsive dermatoses. Desoximetasone is a potent synthetic glucocorticoid that reduces inflammation, redness, and itching by activating natural substances in the skin to suppress immune responses. Salicylic acid acts as a keratolytic agent, softening and loosening dry or scaly skin by breaking down keratin, which helps remove scales and enhances penetration of the corticosteroid component[2][3][7]. This combination leverages both anti-inflammatory (desoximetasone) and exfoliative (salicylic acid) mechanisms to improve symptoms in chronic dermatological disorders.

Other names
salicylic acid 1% / desoximetasone 0.25% lotion
02

Targets

GR (Glucocorticoid receptor)

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