desoxycorticosterone pivalate

Desoxycorticosterone pivalate is a long-acting synthetic mineralocorticoid hormone and an analog of desoxycorticosterone. It is primarily used as a replacement therapy for mineralocorticoid deficiency in dogs with primary hypoadrenocorticism (Addison’s disease). The drug mimics the effects of endogenous aldosterone by increasing sodium retention and promoting potassium excretion in the kidneys. Mechanistically, it acts as an agonist at the mineralocorticoid receptor; after binding to this receptor, it forms a steroid-receptor complex that translocates to the nucleus and induces transcription of specific proteins responsible for electrolyte balance. Desoxycorticosterone pivalate has little or no glucocorticoid activity and should be used alongside appropriate glucocorticoid therapy when treating Addison’s disease[1][2][4][5][6].

Brand names

Percorten-VZycortal

Other names

desoxycorticosterone pivalate21-(2,2-dimethyl-1-oxopropoxy)-pregn-4-ene-3,20-dione