Drug intelligence / Profile preview

desvancosaminyl vancomycin

Development stage
Unknown
Modality
Cyclic Peptides → Modified Peptides → Peptides, Small Molecules
01

Overview

Desvancosaminyl vancomycin is a synthetic derivative of the glycopeptide antibiotic vancomycin, in which the vancosamine sugar moiety has been removed. It is also referred to as pseudovancomycin or vancomycin pseudoaglycone. This compound is primarily used as an impurity standard and research tool rather than a therapeutic agent. Like its parent compound, it retains the core structure responsible for binding to bacterial cell wall precursors but lacks the vancosamine group, which may alter its antimicrobial activity profile. Desvancosaminyl vancomycin has not been approved for clinical use and remains an experimental molecule[1][4][9].

Other names
pseudovancomycinvancomycin pseudoaglycone
02

Targets

D-Ala-D-Ala (D-Ala-D-Ala terminus)GtfA (Glycosyltransferase GtfA)Gtf (Streptococcus mutans glucosyltransferase)PBP (Penicillin-binding protein family)

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