Drug intelligence / Profile preview

DETOPS

Development stage
Preclinical
Lead developer
AntiRadical Therapeutics
Modality
Small Molecules
01

Overview

DETOPS is a small molecule therapeutic featuring stable nitroxide free radicals, developed by AntiRadical Therapeutics. It functions primarily as a superoxide dismutase (SOD) mimetic, replicating the activity of endogenous SOD to neutralize reactive oxygen species and mitigate oxidative stress. Beyond its antioxidant capacity, DETOPS is designed to modulate nitric oxide pathways, cellular signaling, and vascular dynamics. The compound is being developed to address a spectrum of age-related pathologies, including cardiovascular diseases, neurodegenerative disorders, osteoporosis, and metabolic conditions such as diabetes, aiming to enhance cellular resilience and extend healthspan. Preclinical studies have indicated its potential to improve cellular functionality and immune response in aging populations.

02

Targets

Misfolded SOD1

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