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detoxified lipooligosaccharide-tetanus toxoid conjugate
- Development stage
- Unknown
- Lead developer
- National Institute on Deafness and other Communication Disorders
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
**Detoxified lipooligosaccharide-tetanus toxoid conjugate** is an investigational **nontypeable *Haemophilus influenzae* vaccine** developed by the National Institute on Deafness and Other Communication Disorders. It consists of detoxified lipooligosaccharide derived from nontypeable *Haemophilus influenzae* covalently conjugated to tetanus toxoid as a carrier protein. The conjugate is designed to induce anti-lipooligosaccharide antibodies with complement-mediated bactericidal activity against *H. influenzae*, thereby preventing *H. influenzae*-associated otitis media and respiratory tract infection. A Phase I study in healthy adults evaluated intramuscular administration and reported acceptable safety and increased serum anti-lipooligosaccharide antibody responses; no subsequent human development has been identified.
- Other names
- dLOS-TTlipooligosaccharide-tetanus toxoid conjugateNTHi dLOS-TT conjugate
02
Targets
BCR (Immunoglobulin G B Cell Receptor)T-cell receptor recognizing tetanus toxoid-derived peptide–MHC complex
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