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deulumateperone
- Development stage
- Phase 3
- Lead developer
- Intra-Cellular Therapies
- Modality
- Small Molecules
- Administration
- Sublingual, Oral
01
Overview
Deulumateperone (developmental code name ITI-1284) is an experimental antipsychotic and a deuterated analogue of lumateperone. It is being developed as a sublingually administered orally disintegrating tablet (ODT) for the treatment of psychotic disorders, agitation (including in Alzheimer’s disease), generalized anxiety disorder, and behavioral disturbances in dementia. The drug acts as a serotonin 5-HT2A receptor antagonist, dopamine D1 and D2 receptor modulator, glutamate modulator, and serotonin uptake inhibitor. Deulumateperone is being developed by Intra-Cellular Therapies[3][5][6][8].
- Other names
- lumateperone deuterateddeuterated lumateperone
02
Targets
DRD1 (Dopamine D1 Receptor)HTR2A (Serotonin receptor 5-HT2A)SERT (Sodium-dependent serotonin transporter)DRD2 (Dopamine D2 Receptor)
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