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DEVIT-3 is a vitamin D3 (cholecalciferol) supplement available in various formulations, including oral drops, oral solution, and intramuscular injection. It's primarily used to treat and prevent vitamin D deficiency, which is essential for healthy bones, muscles, nerves, and immune system function. ## Formulations and Dosage DEVIT-3 comes in several strengths: - 300,000 IU/ml solution for intramuscular injection - 50,000 IU/15ml oral drops The medication is typically administered as directed by a healthcare provider, with dosage based on the patient's medical condition, sun exposure, diet, age, and response to treatment[1][2]. ## Uses and Indications DEVIT-3 is indicated for: - Treatment and prevention of vitamin D deficiency, particularly in patients with gastrointestinal absorption disorders[2] - Prevention and treatment of bone disorders such as rickets (in children) and osteomalacia (in adults)[1][3] - Management of osteoporosis when used with calcium[3] - Support for patients with hypoparathyroidism, pseudohypoparathyroidism, and familial hypophosphatemia[3] - Maintaining normal calcium levels in kidney disease patients[4] ## How It Works Vitamin D3 (cholecalciferol) is synthesized in the skin following sunlight exposure and is then converted in the liver to calcifediol (25-hydroxycholecalciferol), which is further converted in the kidney to calcitriol (1,25-dihydroxycholecalciferol)[6]. This active form promotes calcium absorption in the intestines, helping to maintain proper calcium levels in the blood and supporting bone health[6]. ## Administration For oral formulations: - Take as directed, typically once or twice daily - May be taken with or without food, though it's best absorbed when taken after a meal - For liquid forms, carefully measure the dose using a special measuring device - For children, drops may be added to food or drink[3][4] For injectable formulations: - Administered via intramuscular injection by healthcare professionals[2][5] ## Side Effects and Precautions DEVIT-3 should not be used by patients with: - Hypercalcemia (increased calcium concentration in blood) - Known allergies to cholecalciferol or other ingredients[2] Excessive doses can lead to vitamin D toxicity (hypervitaminosis D), which may cause symptoms such as vomiting, constipation, muscle weakness, and confusion[6]. ## Manufacturer DEVIT-3 is manufactured by DEVA Holding A.Ş., based in Turkey[2][5].
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