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DEX-PRESSIN
- Development stage
- Unknown
- Lead developer
- Mansoura University
- Modality
- Peptides, Small Molecules
- Administration
- Intravenous
01
Overview
**DEX-PRESSIN** is an investigational decatecholaminization treatment strategy for **septic shock** that combines first-line intravenous vasopressin with a heart rate-calibrated intravenous dexmedetomidine infusion. Vasopressin is used as a non-catecholamine vasopressor through vasopressin V1a receptor agonism, while dexmedetomidine is a central alpha-2 adrenergic receptor agonist that provides sympatholysis and can reduce endogenous and exogenous catecholamine exposure. Mansoura University is evaluating this co-administration regimen in the Phase 2 DecatSepsis-2 randomized trial for its potential to reduce in-hospital mortality in adults with septic shock.
- Other names
- Dex-pressin
02
Targets
ADRA2C (α2C)ADRA2A (α2A)AVPR2 (Arginine vasopressin V2 receptor)AVPR1A (Arginine vasopressin receptor 1A)ADRA2B (α2B)
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